Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities
نویسندگان
چکیده
منابع مشابه
Mouse models for Down syndrome-associated developmental cognitive disabilities.
Down syndrome (DS) is mainly caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is a leading genetic cause for developmental cognitive disabilities in humans. The mouse is a premier model organism for DS because the regions on Hsa21 are syntenically conserved with three regions in the mouse genome, which are located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. With t...
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Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of chromosome 21. DS affects multiple organs, but it invariably results in altered brain development and diverse degrees of intellectual disability. A large body of evidence has shown that synaptic deficits and memory impairment are largely determined by altered GABAergic signaling in trisomic mouse models of DS. Th...
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Down syndrome (DS) is caused by the overexpression of genes on triplicated regions of human chromosome 21 (Hsa21). While the resulting physiological and behavioral phenotypes vary in their penetrance and severity, all individuals with DS have variable but significant levels of cognitive disability. At the core of cognitive processes is the phenomenon of synaptic plasticity, a functional change ...
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Down syndrome (DS) is the most common genetic form of intellectual disability. DS results in a characteristic profile of cognitive and neurological dysfunction. The predominant theory of the pattern of neural deficits in this syndrome suggests that DS affects 'late-developing' neural systems, including the function of the prefrontal cortex and hippocampus. In order to evaluate the validity of this...
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ژورنال
عنوان ژورنال: Developmental Neuroscience
سال: 2011
ISSN: 1421-9859,0378-5866
DOI: 10.1159/000329422